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Neurochemical Characterization of PSA-NCAM+ Cells in the Human Brain and Phenotypic Quantification in Alzheimer's Disease Entorhinal Cortex.

Neuroscience - 21 Feb 2018

Murray Helen C, Swanson Molly E V, Dieriks B Victor, Turner Clinton, Faull Richard L M, Curtis Maurice A

Abstract excerpt

Polysialylated neural cell adhesion molecule (PSA-NCAM) is widely expressed in the adult human brain and facilitates structural remodeling of cells through steric inhibition of intercellular NCAM adhesion. We previously showed that PSA-NCAM immunoreactivity is decreased in the entorhinal cortex in Alzheimer's disease (AD). Based on available evidence, we hypothesized that a loss of PSA-NCAM+ interneurons may...

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PMID: 29429526
DOI: 10.1016/j.neuroscience.2017.12.019

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