Article

Integrative transcriptomic and single-nucleus analyses identify ZEB1 as a key regulator of ovarian aging in granulosa cells

2026-04-30

Abstract excerpt

<title>Abstract</title> <p>Background Ovarian aging is characterized by a progressive decline in follicular quantity and quality, in which granulosa cell (GC) dysfunction plays a central role. Although transcriptomic alterations associated with GC aging have been reported, the cellular heterogeneity underlying these changes and the key regulatory mechanisms involved remain incompletely understood. Methods We in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0f0d531f-410d-5c1a-a8b5-4255da1410f2
DOI: 10.21203/rs.3.rs-9045470/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative transcriptomic and single-nucleus analyses identify ZEB1 as a key regulator of ovarian aging in granulosa cellsDOI 10.21203/rs.3.rs-9045470/v1Read

Multiomics analyses reveal key circadian rhythm genes implicated in Premature ovarian insufficiencySemantic proximity Read

Spatiotemporal analysis of human ovarian aging at single-cell resolutionSemantic proximity Read

Single-cell exploration of ovarian aging across vertebrate modelsSemantic proximity Read

Spatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1Semantic proximity Read

Long non-coding ribonucleic acid SNHG18 induced human granulosa cell apoptosis via disruption of glycolysis in ovarian agingSemantic proximity Read

The regulatory landscapes of human ovarian ageingSemantic proximity Read

Single-cell transcriptomic atlas of goat ovarian agingSemantic proximity Read

An Oxidative Stress‐Related Gene Signature in Granulosa Cells Is Associated with Ovarian AgingSemantic proximity Read

Molecular mechanisms regulating natural menopause in the female ovary: a study based on transcriptomic dataSemantic proximity Read

Integrated analyses of the single-cell ATAC-seq and RNA-seq reveal the epigenetic landscape of human ovarian agingSemantic proximity Read

Molecular and genetic insights into human ovarian aging from single-nuclei multi-omics analysesSemantic proximity Read