Article

Social stress worsens colitis through β-adrenergic–driven oxidative stress in intestinal mucosal compartments

2025-07-18

Abstract excerpt

<h4> Abstract </h4> Psychological stress is a known risk factor for inflammatory bowel disease (IBD), but the mechanisms linking stress to worsened disease remain unclear. Because distinct stress paradigms activate different neuroimmune circuits, it is critical to investigate model-specific effects. We examined how social stress primes the gut for heightened inflammation and whether this is mediated by specific...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 595c4fb3-37c3-5c9c-b599-b634df376d39
DOI: 10.1101/2025.07.15.664961

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Social stress worsens colitis through β-adrenergic–driven oxidative stress in intestinal mucosal compartmentsDOI 10.1101/2025.07.15.664961Read

Psychological stress disrupts intestinal epithelial cell function and mucosal integrity through microbe and host-directed processesSemantic proximity Read

Psychological stress disrupts intestinal epithelial cell function and mucosal integrity through microbe and host-directed processesSemantic proximity Read

Stress-activated brain-gut circuits disrupt intestinal barrier integrity and social behaviourSemantic proximity Read

Social stress causes gut dysbiosis in male, female, and aggressor miceSemantic proximity Read

Chronic stress exposure alters the gut barrier: sex-specific effects on microbiota and jejunum tight junctionsSemantic proximity Read

Early-life gut microbiome and stress-axis perturbations dysregulate systemic, mucosal, and brain immunitySemantic proximity Read

Communication of gut microbiota and brain via immune and neuroendocrine signalingSemantic proximity Read

Chronic Psychological Stress Disrupted the Composition of the Murine Colonic Microbiota and Accelerated a Murine Model of Inflammatory Bowel DiseaseSemantic proximity Read

The structures of the colonic mucosa-associated and luminal microbial communities are distinct and differentially affected by a prolonged murine stressorSemantic proximity Read

The gut–brain axis in irritable bowel syndrome: neuroendocrine and epigenetic pathwaysSemantic proximity Read

DSS Colitis Model: Traps, Tricks, and Reporting RecommendationsSemantic proximity Read

Role of probiotics in correcting abnormalities of colonic flora induced by stress: Figure 1Semantic proximity Read