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Genome integrity, somatic mutation, and the N-of-1 imperative in aging research.

Biogerontology - 4 Jun 2026

Govindaraju Diddahally R, Atzmon Gil, Innan Hideki, Veitia Reiner A

Abstract excerpt

Aging research has made remarkable progress in describing aging through the genetic architecture of longevity, epigenetic clocks, proteomic signatures, and systems-level analyses. Yet a critical dimension remains underrepresented: the role of genome integrity, germline and somatic mutation accumulation in individual-specific vulnerability, frailty, and multimorbidity across the life course. The need for...

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PMID: 42240775
DOI: 10.1007/s10522-026-10451-y

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