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Article

The Muller's Ratchet and Aging.

Trends in genetics : TIG - 1 Jun 2020

Govindaraju Diddahally R, Innan Hideki, Veitia Reiner A

Abstract excerpt

Aging entails an irreversible deceleration of physiological processes, altered metabolic activities, and a decline of the integrity of tissues, organs, and organ systems. The accumulation of alterations in the genetic and epigenetic spaces has been proposed as an explanation for aging. They result, at least in part, from DNA replication and chromosome segregation errors due to cell division during development,...

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PMID: 32396833
DOI: 10.1016/j.tig.2020.02.004

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