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Article

A comparison of three methods for detecting KRAS mutations in formalin-fixed colorectal cancer specimens.

British journal of cancer - 10 Jul 2012

Gonzalez de Castro D, Angulo B, Gomez B, Mair D, Martinez R, Suarez-Gauthier A, Shieh F, Velez M, Brophy V H, Lawrence H J, Lopez-Rios F

Abstract excerpt

BACKGROUND: KRAS mutation testing is required to select patients with metastatic colorectal cancer (CRC) to receive anti-epidermal growth factor receptor antibodies, but the optimal KRAS mutation test method is uncertain. METHODS: We conducted a two-site comparison of two commercial KRAS mutation kits - the cobas KRAS Mutation Test and the Qiagen therascreen KRAS Kit - and Sanger sequencing. A panel of 120 CRC...

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Source

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Identifiers

PMID: 22713664
DOI: 10.1038/bjc.2012.259
PMCID: PMC3394984

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A comparison of three methods for detecting KRAS mutations in formalin-fixed colorectal cancer specimens.PMID 22713664Read ↗

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Performance evaluation comparison of 3 commercially available PCR-based KRAS mutation testing platforms.Semantic proximity Read ↗

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Novel Approach for Clinical Validation of the cobas KRAS Mutation Test in Advanced Colorectal Cancer.Semantic proximity Read ↗

KRAS mutations: analytical considerations.Semantic proximity Read ↗

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KRAS gene mutation in a series of unselected colorectal carcinoma patients with prognostic morphological correlations: a pyrosequencing method improved by nested PCR.Semantic proximity Read ↗

KRAS testing and its importance in colorectal cancer.Semantic proximity Read ↗

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