Article

Decoupling the correlation between cytotoxic and exhausted T lymphocyte transcriptomic signatures enhances melanoma immunotherapy response prediction from tumor expression

2023-01-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Cytotoxic T lymphocytes (CTL) play a crucial role in anti-cancer immunity. Progression of CTL to terminal exhausted T lymphocytes (ETL) that overexpress inhibitory receptors can substantially decrease effector cytokines production and diminish cytolytic activity and terminal exhausted T cell cannot be reprogrammed by ICIs in tumor microenvironment (TME). However, while the a...

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Literature Corpus work: 593dddf4-4917-57e4-b399-bd5aa39ef4fb
DOI: 10.1101/2023.01.17.524482

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