Article

Pan-cancer prediction of tumor immune activation and response to immune checkpoint blockade from tumor transcriptomics and histopathology

2025-06-30

Abstract excerpt

Accurately predicting which patients will respond to immune checkpoint blockade (ICB) remains a major challenge. Here, we present TIME_ACT, an unsupervised 66-gene transcriptomic signature of tumor immune activation derived from TCGA melanoma data. First, TIME_ACT scores accurately identify tumors with activated immune microenvironments across cancer types. Analysis of spatial features of the tumor microenvironmen...

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Literature Corpus work: b3c1ae9c-e7ed-5c5c-8f29-4e79fbd18f43
DOI: 10.1101/2025.06.27.661875

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