Article

Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer’s disease progression

2023-10-16

Abstract excerpt

Loss of m Ca 2+ efflux capacity contributes to the pathogenesis and progression of Alzheimer’s disease (AD) by promoting mitochondrial Ca 2+ ( m Ca 2+ ) overload. Here, we utilized loss-of-function genetic mouse models to causally evaluate the role of m Ca 2+ uptake by conditionally deleting the mitochondrial calcium uniporter channel (mtCU) in a robust mouse model of AD. Loss of neuronal m Ca 2+ uptake r...

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Literature Corpus work: 5934f88e-62eb-5523-93fb-7bb65c3ac154
DOI: 10.1101/2023.10.11.561889

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