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Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats

13 May 2023

Abstract excerpt

Abstract The common pathogenesis of Alzheimer’s disease (AD) and Parkinson’s disease (PD) has been supported by biochemical, genetic and molecular evidence. Mitochondrial dysfunction is considered to be the common pathology in early AD and PD. The physiological regulation of APP and α-synuclein on mitochondria remains unclear, let alone whether they share common regulatory mechanisms affecting the development of...

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PMID: 37179386
DOI: 10.1038/s41419-023-05846-5

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