Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gpnmb and Spp1 mark a conserved macrophage injury response masking fibrosis-specific programming in the lung

7 Nov 2024

Abstract excerpt

Macrophages are required for healthy repair of the lungs following injury, but they are also implicated in driving dysregulated repair with fibrosis. How these 2 distinct outcomes of lung injury are mediated by different macrophage subsets is unknown. To assess this, single-cell RNA-Seq was performed on lung macrophages isolated from mice treated with LPS or bleomycin. Macrophages were categorized based on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Frailty in Older Adults
Share to Medical Imaging and Pathology Studies
Share to Tissue Engineering and Regenerative Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39509324
DOI: 10.1172/jci.insight.182700

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gpnmb and Spp1 mark a conserved macrophage injury response masking fibrosis-specific programming in the lungPMID 39509324Read ↗

Induction of a distinct macrophage population and protection from lung injury and fibrosis by Notch2 blockadeSemantic proximity Read ↗

The guardians of pulmonary harmony: alveolar macrophages orchestrating the symphony of lung inflammation and tissue homeostasis.Semantic proximity Read ↗

Reference-based annotation of single cell transcriptomes identifies a profibrotic macrophage niche after tissue injurySemantic proximity Read ↗

Pulmonary Macrophages: A New Therapeutic Pathway in Fibrosing Lung Disease?Semantic proximity Read ↗

Spatial and phenotypic heterogeneity of resident and monocyte-derived macrophages during inflammatory exacerbations leading to pulmonary fibrosis.Semantic proximity Read ↗

Systems Level Identification of a Matrisome-Associated Macrophage Polarization State in Multi-Organ FibrosisSemantic proximity Read ↗

Single-Cell RNA Sequencing Reveals Monocyte-Derived Interstitial Macrophages with a Pro-Fibrotic Phenotype in Bleomycin-Induced Pulmonary Fibrosis.Semantic proximity Read ↗

Early-stage idiopathic pulmonary fibrosis is characterized by bronchoalveolar accumulation of SPP1 <sup>+</sup> macrophagesSemantic proximity Read ↗

Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19Semantic proximity Read ↗

Systems level identification of a matrisome-associated macrophage polarisation state in multi-organ fibrosisSemantic proximity Read ↗

Redefining inflammatory macrophage phenotypes across stages and tissues by single-cell transcriptomics.Semantic proximity Read ↗

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.