Article

FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality control

2023-04-14

Abstract excerpt

<title>Abstract</title> <p>Mitochondrial dysfunction and oxidative stress are important mechanisms for secondary injury after traumatic brain injury (TBI), which result in progressive pathophysiological exacerbation. Although the Fibronectin type III domain-containing 5 (FNDC5) was reported to repress oxidative stress by retaining mitochondrial biogenesis and dynamics, while its possible role in the secondary inj...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 58fa8895-3073-5faa-8b31-ecb157f8d038
DOI: 10.21203/rs.3.rs-2633781/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

FNDC5 prevents oxidative stress and neuronal apoptosis after traumatic brain injury through SIRT3-dependent regulation of mitochondrial quality controlDOI 10.21203/rs.3.rs-2633781/v1Read

Ferrostatin-1 Alleviates White Matter Injury via Decreasing Ferroptosis Following Spinal Cord InjurySemantic proximity Read

Integrative analysis of TBI data reveals Lgmn as a key player in immune cell-mediated ferroptosisSemantic proximity Read

FNDC5/Irisin System in Neuroinflammation and Neurodegenerative Diseases: Update and Novel PerspectiveSemantic proximity Read

Role and Functions of Irisin: A Perspective on Recent Developments and Neurodegenerative DiseasesSemantic proximity Read

Identification of Ferroptotic Genes in Spinal Cord Injury at Different Time Points: Bioinformatics and Experimental ValidationSemantic proximity Read

Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injurySemantic proximity Read

Repair spinal cord injury with a versatile anti-oxidant and neural regenerative nanoplatformSemantic proximity Read

Neutrophil extracellular traps promote neuronal ferroptosis through STING-mediated AMPK dysregulation after traumatic brain injurySemantic proximity Read

A proteomics-based approach reveals the role of the activation of astrocytes with the A1 phenotype in medullary neuroinflammation after TBI in mice.Semantic proximity Read

TRAF6-Mediated Ubiquitin Signaling Drives Long-Term Neurodegeneration in a Mouse Model of Chronic Traumatic EncephalopathySemantic proximity Read

Progress and Challenges in the Biology of FNDC5 and IrisinSemantic proximity Read

FNDC5/irisin mediates hallmark brain alterations and cognitive impairment in acute intestinal injury/diseaseSemantic proximity Read