Article

Single-cell atlas of intracranial arteries reveals sex-specific gene regulation linked to intracranial aneurysm risk

2025-11-10

Abstract excerpt

<h4>BACKGROUND</h4> Rupture of an intracranial aneurysm (IA) results in aneurysmal subarachnoid hemorrhage, a severe form of stroke that is more prevalent in women than in men. The biological mechanisms underlying IA formation and the observed sex differences in prevalence in women remain poorly understood. Here, we present a single-cell RNA sequencing (scRNA-seq) atlas of intracranial arteries and use it to anal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 58f7ba5a-901c-5170-a0c7-6b42b5dc8e35
DOI: 10.1101/2025.11.06.25339724

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell atlas of intracranial arteries reveals sex-specific gene regulation linked to intracranial aneurysm riskDOI 10.1101/2025.11.06.25339724Read

Single-cell RNA analysis reveals the cell atlas of human intracranial aneurysm and rupture-related inflammation featuresSemantic proximity Read

Single-cell transcriptome analysis reveals the cellular atlas of human intracranial aneurysm and highlights inflammation features associated with aneurysm ruptureSemantic proximity Read

Single-cell analysis reveals the implication of vascular endothelial cell-intrinsic ANGPT2 in human intracranial aneurysm.Semantic proximity Read

Single-Cell Transcriptome Analysis of the Circle of Willis in a Mouse Cerebral Aneurysm ModelSemantic proximity Read

Identifying novel risk genes in intracranial aneurysm by integrating human proteomes and genetics.Semantic proximity Read

Single-cell sequencing combined with Mendelian randomization to explore the molecular mechanisms related to abdominal aortic aneurysmSemantic proximity Read

Integrative analysis of single-cell sequencing, bulk transcriptomics and experimental verification reveals key molecular mechanisms of vascular smooth muscle cells involved in intracranial aneurysm progressionSemantic proximity Read

Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors.Semantic proximity Read

Dissecting the Genetic Architecture of Intracranial AneurysmsSemantic proximity Read

Region-specific gene expression and sex inform about disease susceptibility in the aortaSemantic proximity Read

Sex-Specific X-Chromosome Gene Expression in Intracranial AneurysmsSemantic proximity Read

Molecular characteristics of arteries in patients with intracranial aneurysm: integration of WES and RNA-seqSemantic proximity Read