Single-Cell Transcriptome Analysis of the Circle of Willis in a Mouse Cerebral Aneurysm Model

Abstract excerpt

BACKGROUND: The circle of Willis (CoW) is the most common location for aneurysms to form in humans. Although the major cell types of the intracranial vasculature are well known, the heterogeneity and relative contributions of the different cells in healthy and aneurysmal vessels have not been well characterized. Here, we present the first comprehensive analysis of the lineage heterogeneity and altered...

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