Article

A graph-theoretic model of single point mutations in the cystic fibrosis transmembrane conductance regulator

2016-06-17

Abstract excerpt

Cystic fibrosis is one of the most prevalent inherited diseases. This disease is caused by a mutation in a membrane protein, the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is known to function as a chloride channel that regulates the viscosity of mucus that lines the ducts of a number of organs. The most prevalent mutation of CFTR is located in one of two nucleotide binding domains, namely, t...

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Literature Corpus work: 58e5ea8d-841e-5b9e-a9f5-3fc6240102d0
DOI: 10.24297/jbt.v6i1.4013

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