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Article

Disease-relevant mutations alter amino acid co-evolution networks in the second nucleotide binding domain of CFTR.

PloS one - 1 Jan 2020

Ivey Gabrianne, Youker Robert T

Abstract excerpt

Cystic Fibrosis (CF) is an inherited disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel. Mutations in CFTR cause impaired chloride ion transport in the epithelial tissues of patients leading to cardiopulmonary decline and pancreatic insufficiency in the most severely affected patients. CFTR is composed of twelve membrane-spanning domains, two...

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Source

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Identifiers

PMID: 31978131
DOI: 10.1371/journal.pone.0227668
PMCID: PMC6980524

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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