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Article

Stability Prediction for Mutations in the Cytosolic Domains of Cystic Fibrosis Transmembrane Conductance Regulator.

Journal of chemical information and modeling - 26 Apr 2021

Bahia Malkeet Singh, Khazanov Netaly, Zhou Qingxian, Yang Zhengrong, Wang Chi, Hong Jeong S, Rab Andras, Sorscher Eric J, Brouillette Christie G, Hunt John F, Senderowitz Hanoch

Abstract excerpt

Cystic Fibrosis (CF) is caused by mutations to the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channel. CFTR is composed of two membrane spanning domains, two cytosolic nucleotide-binding domains (NBD1 and NBD2) and a largely unstructured R-domain. Multiple CF-causing mutations reside in the NBDs and some are known to compromise the stability of these domains. The ability to predict the...

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Identifiers

PMID: 33720715
DOI: 10.1021/acs.jcim.0c01207
PMCID: PMC10230551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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