Article

An antisense RNA capable of modulating the expression of the tumor suppressor microRNA-34a

2017-12-15

Abstract excerpt

The microRNA-34a is a well-studied tumor suppressor microRNA (miRNA) and a direct downstream target of TP53 with roles in several pathways associated with oncogenesis, such as proliferation, cellular growth, and differentiation. Due to its broad tumor suppressive activity, it is not surprising that miR34a expression is altered in a wide variety of solid tumors and hematological malignancies. However, the mechanis...

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Literature Corpus work: 58e2e323-6718-5f0a-bbad-461a71bae3b8
DOI: 10.1101/234310

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