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Targeting of miR34a–NOTCH1 Axis Reduced Breast Cancer Stemness and Chemoresistance

4 Nov 2014

Abstract excerpt

Human breast cancers include cancer stem cell populations as well as nontumorigenic cancer cells. Breast cancer stem cells have self-renewal capability and are resistant to conventional chemotherapy. miRNAs regulate the expression of many target genes; therefore, dysregulation of miRNAs has been associated with the pathogenesis of human diseases, including cancer. However, a role for miRNA dysregulation in...

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PMID: 25368020
DOI: 10.1158/0008-5472.can-14-1140

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