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Article

Evolution of the conformational dynamics of the molecular chaperone Hsp90.

Nature communications - 4 Oct 2024

Riedl Stefan, Bilgen Ecenaz, Agam Ganesh, Hirvonen Viivi, Jussupow Alexander, Tippl Franziska, Riedl Maximilian, Maier Andreas, Becker Christian F W, Kaila Ville R I, Lamb Don C, Buchner Johannes

Abstract excerpt

Hsp90 is a molecular chaperone of central importance for protein homeostasis in the cytosol of eukaryotic cells, with key functional and structural traits conserved from yeast to man. During evolution, Hsp90 has gained additional functional importance, leading to an increased number of interacting co-chaperones and client proteins. Here, we show that the overall conformational transitions coupled to the ATPase...

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Identifiers

PMID: 39366960
DOI: 10.1038/s41467-024-52995-y
PMCID: PMC11452706

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