Article

Epitomic analysis of the specificity of conformation-dependent, anti-Aß amyloid monoclonal antibodies

2020-08-05

Abstract excerpt

Antibodies against Aß amyloid are indispensable research tools and potential therapeutics for Alzheimer’s Disease, but display several unusual properties, such as specificity for aggregated forms of the peptide, ability to distinguish polymorphic aggregate structures and ability to recognize generic aggregation-related epitopes formed by unrelated amyloid sequences. Understanding the mechanisms underlying these un...

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Literature Corpus work: 58a05c71-0482-5bd9-9b7a-85d401443ac7
DOI: 10.1101/2020.08.05.238105

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