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The diversity of disease-associated natural human antibody specificities declines dramatically in Alzheimer’s disease

2026-07-24

Abstract excerpt

Alzheimer’s disease (AD) is the leading cause of dementia and administration of monoclonal antibodies against Aβ amyloid are associated with disease modifying effects leading to FDA approval for some antibodies. Naturally-occurring human antibodies (NAbs) are believed to be the front line of defense against a variety of diseases, so we investigated the specificity of NAbs in AD and cognitively normal (NC) individu...

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Literature Corpus work
7798001a-2559-5345-8b2b-d867072e01f6
DOI
10.64898/2026.07.21.739870
Open publication

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The diversity of disease-associated natural human antibody specificities declines dramatically in Alzheimer’s diseaseDOI 10.64898/2026.07.21.739870
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