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Radiochemical Synthesis and Evaluation of 3-[ <sup>11</sup> C]Methyl-4-aminopyridine in Rodents and Non-Human Primates for Imaging Potassium Channels in the CNS

2022-06-26

Abstract excerpt

Demyelination, the loss of the insulating sheath of neurons, causes failed or slowed neuronal conduction and contributes to the neurological symptoms in multiple sclerosis, traumatic brain and spinal cord injuries, stroke, and dementia. In demyelinated neurons, the axonal potassium channels K v 1.1 and K v 1.2, generally under the myelin sheath, become exposed and upregulated. Therefore, imaging these channels u...

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Literature Corpus work
586ba5b1-56cc-5f5f-a33f-ff31d5d010c2
DOI
10.1101/2022.06.22.495540
Open publication

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Radiochemical Synthesis and Evaluation of 3-[ <sup>11</sup> C]Methyl-4-aminopyridine in Rodents and Non-Human Primates for Imaging Potassium Channels in the CNSDOI 10.1101/2022.06.22.495540
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