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Synthesis and Initial <i>in Vivo</i> Studies with [ <sup>11</sup> C]SB-216763: The First Radiolabeled Brain Penetrative Inhibitor of GSK-3

10 Mar 2015

Abstract excerpt

Quantifying glycogen synthase kinase-3 (GSK-3) activity in vivo using positron emission tomography (PET) imaging is of interest because dysregulation of GSK-3 is implicated in numerous diseases and neurological disorders for which GSK-3 inhibitors are being considered as therapeutic strategies. Previous PET radiotracers for GSK-3 have been reported, but none of the published examples cross the blood-brain...

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PMID: 26005531
DOI: 10.1021/acsmedchemlett.5b00044

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