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From Circuit Descriptions to Testable Mechanism Space in PTSD: A Minimal, Identifiability-Aware Computational Framework for Heterogeneous Threat Inference

2026-02-11

Abstract excerpt

Post-traumatic stress disorder (PTSD) is commonly described in terms of frontolimbic circuit alterations and stress-system dysregulation. Yet the central translational problem remains mechanistic: patients with similar symptom severity can differ in why fear persists, why safety fails under stress, and why relapse follows context shifts. Here we synthesize convergent evidence across fear circuitry, noradrenergic a...

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Literature Corpus work
d71a60ed-b152-5055-babf-3136cba3328c
DOI
10.32388/76fbo7.3
Open publication

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