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Article

SIRT1 Undergoes Alternative Splicing in a Novel Auto-Regulatory Loop with p53

21 Oct 2010

Abstract excerpt

BACKGROUND: The NAD-dependent deacetylase SIRT1 is a nutrient-sensitive coordinator of stress-tolerance, multiple homeostatic processes and healthspan, while p53 is a stress-responsive transcription factor and our paramount tumour suppressor. Thus, SIRT1-mediated inhibition of p53 has been identified as a key node in the common biology of cancer, metabolism, development and ageing. However, precisely how SIRT1...

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PMID: 20975832
DOI: 10.1371/journal.pone.0013502

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