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Article

Computational Insights into SIRT1: Elucidating Mutational Impact on SIRT1-RECQL4 Structural Dynamics.

Cell biochemistry and biophysics - 1 Jun 2026

Anand Shrikirti, Patel Trupti N

Abstract excerpt

SIRT1 (silent mating type information regulation 2 homolog 1) functions as a versatile regulatory protein that modulates metabolism, epigenetic states, and DNA repair, thereby playing a critical role in maintaining cellular homeostasis. As a major protein deacetylase, SIRT1 acts on multiple substrates, with RECQL4 being a prominent DNA repair target. SIRT1-mediated deacetylation of RECQL4 regulates DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41776022
DOI: 10.1007/s12013-026-02037-9

Genes

SIRT1
RECQL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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