Article

An intragenic FAT1 regulatory element deleted in muscular dystrophy patients drives muscle and mesenchyme expression during development

2022-09-17

Abstract excerpt

<h4>Summary</h4> Fat1 is an atypical cadherin playing multiple roles that influence tissue morphogenesis. During mouse development Fat1 is required to modulate muscle morphogenesis through complementary activities in myogenic cells, muscle-associated connective tissue, and motor neurons, ablation of which leads to regionalized muscle phenotypes. We previously identified copy number variants (CNV) deleting an intr...

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Literature Corpus work: 57fbd19a-0070-5724-8b8e-7c227c85648b
DOI: 10.1101/2022.09.14.507898

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