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Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis

19 Jan 2023

Abstract excerpt

Richter syndrome (RS) is the transformation of chronic lymphocytic leukemia (CLL) into aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL). We characterize 58 primary human RS samples by genome-wide DNA methylation and whole-transcriptome profiling. Our comprehensive approach determines RS DNA methylation profile and unravels a CLL epigenetic imprint, allowing CLL-RS clonal relationship...

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PMID: 36658118
DOI: 10.1038/s41467-022-34642-6

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