Article
Differential genomic and transcriptomic events associated with high-grade transformation of Chronic Lymphocytic Leukemia
2019-05-21
Abstract excerpt
The transformation of chronic lymphocytic leukemia (CLL) to high-grade diffuse large B-cell lymphoma (DLBCL), also called Richter’s Syndrome (RS), is a rare cancer with dismal prognosis. Drug discovery for RS is hampered by the lack of suitable experimental models, and effective therapies remain elusive rendering RS an area of high unmet clinical need. We performed whole genome sequencing (WGS) to interrogate pair...
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Identifiers and source
- Literature Corpus work
- 411c334b-950f-539a-b26d-20684a48682f
- DOI
- 10.1101/644542