Back to search

Article

Inhibition of Microbial Beta-Glucuronidase Does Not Prevent Breast Carcinogenesis in the Polyoma Middle T Mouse

2019-08-24

Abstract excerpt

<h4>Purpose</h4> To demonstrate whether inhibition of intestinal microbial beta (β)-glucuronidase (BGUS) abrogates tumor formation in a MMTV-PyMT mouse breast cancer model. <h4>Methods</h4> Female MMTV-PyMT heterozygote mice (4 weeks old) were randomized to oral gavage with vehicle or UNC10201652 (20 μg/day), a microbial BGUS inhibitor, for 9 weeks. The entire animal carcass was assessed for tumor deposits by hi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
57dc6aee-04aa-5fe8-9bc2-06db65a72770
DOI
10.1101/746602
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 10 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Inhibition of Microbial Beta-Glucuronidase Does Not Prevent Breast Carcinogenesis in the Polyoma Middle T MouseDOI 10.1101/746602
Inducible and coupled expression of the polyomavirus middle T antigen and Cre recombinase in transgenic mice: an in vivo model for synthetic viability in mammary tumour progressionSemantic proximity
USP22 overexpression fails to augment tumor formation in MMTV-ERBB2 mice but loss of function impacts MMTV promoter activitySemantic proximity
Mass spectrometry imaging shows specific lipids signals linked to Cyp27b1 ablation in the MMTV PyMT breast cancer modelSemantic proximity
Attenuation of TGF-β signaling supports tumor progression of a mesenchymal-like mammary tumor cell line in a syngeneic murine model.Semantic proximity
Mouse skin chemical carcinogenesis is inhibited by antizyme in promotion-sensitive and promotion-resistant genetic backgrounds.Semantic proximity
Impairment of mammary lobular development induced by expression of TGFbeta1 under the control of WAP promoter does not suppress tumorigenesis in MMTV-infected transgenic mice.Semantic proximity
Epithelial Protein-Tyrosine Phosphatase 1B Contributes to the Induction of Mammary Tumors by HER2/Neu but Is Not Essential for Tumor MaintenanceSemantic proximity
Disruption of the Lcn2 gene in mice suppresses primary mammary tumor formation but does not decrease lung metastasisSemantic proximity
Dose-dependent effects of dietary alpha- and gamma-tocopherols on genetic instability in mouse Mutatect tumors.Semantic proximity
Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor.Semantic proximity
Select a neighboring publication to make it the new centre.