Article

Elucidating the molecular landscape of centronuclear myopathies in mouse models: an integrative multi-omics and network analysis

2025-01-03

Abstract excerpt

Centronuclear myopathies (CNM) are rare inherited muscle disorders characterized by muscle atrophy, weakness, and altered muscle fiber structure, primarily due to mutations in genes like MTM1, DNM2, and BIN1. The pathomechanisms implicated in CNM are only partially understood, and no curative therapies are available for patients. This study exploits a unique multi-omics dataset and network-based analyses to elucid...

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Literature Corpus work: 57dc262d-b1c2-59e7-87ae-a2325e253a4a
DOI: 10.1101/2025.01.03.631202

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