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Mitochondrial-related hub genes in dermatomyositis: muscle and skin datasets-based identification and in vivo validation

8 Feb 2024

Abstract excerpt

Background: Mitochondrial dysfunction has been implicated in the pathogenesis of dermatomyositis (DM), a rare autoimmune disease affecting the skin and muscles. However, the genetic basis underlying dysfunctional mitochondria and the development of DM remains incomplete. Methods: The datasets of DM muscle and skin tissues were retrieved from the Gene Expression Omnibus database. The mitochondrial related genes...

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PMID: 38389573
DOI: 10.3389/fgene.2024.1325035

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