Article

Do available protein 3D structures reflect human genetic and functional diversity?

2019-05-17

Abstract excerpt

<h4>ABSTRACT</h4> Genomic databases are substantially biased towards European ancestry populations, and this bias contributes to health disparities. Here, we quantify how well 66,971 experimentally characterized human protein 3D structures represent the diversity of protein sequences observed across the 1000 Genomes Project. More than 85% of available structures do not match a sequence observed in at least one in...

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Literature Corpus work: 57bc7fe7-8a03-5fb7-a60b-9e84425dc24b
DOI: 10.1101/637744

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