Article

Identifying Dihydropyrimidine Dehydrogenase as a Novel Regulator of Hepatic Steatosis

2021-03-04

Abstract excerpt

Pyrimidine catabolism is implicated in hepatic steatosis. Dihydropyrimidine Dehydrogenase (DPYD) is an enzyme responsible for uracil and thymine catabolism, and DPYD human genetic variability affects clinically observed toxicity following 5-Fluorouracil (5-FU) administration. In an in vitro model of diet-induced steatosis, the pharmacologic inhibition of DPYD resulted in protection from lipid accumulation. Additi...

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Literature Corpus work: 57b97b3e-b90c-5b01-a1a5-e9d2198e223f
DOI: 10.1101/2021.03.04.433987

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