Article

Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 drives concurrent 11-oxygenated androgen excess

2023-06-09

Abstract excerpt

Aldo-keto reductase 1C3 (AKR1C3) is a key enzyme in the activation of both classic and 11-oxygenated androgens. In adipose tissue, AKR1C3 is co-expressed with 11β-hydroxysteroid dehydrogenase type 1 (HSD11B1), which catalyses the local activation of glucocorticoids but also the inactivation of 11-oxygenated androgens, and thus has the potential to counteract AKR1C3. Using a combination of in vitro assays and in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 57b649a1-7cb5-5f48-8d18-9bd175da1d51
DOI: 10.1101/2023.06.05.543687

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 drives concurrent 11-oxygenated androgen excessDOI 10.1101/2023.06.05.543687Read

Inhibition of the androgen-activating enzyme AKR1C3 selectively decreases systemic and intra-adipose 11-oxygenated androgens in womenSemantic proximity Read

11 beta-Hydroxysteroid dehydrogenase.Semantic proximity Read

11β-HSD1 inhibitor efficacy in type 2 diabetes is cortisol-dependentSemantic proximity Read

Peripheral blood mononuclear cells preferentially activate 11-oxygenated androgensSemantic proximity Read

11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects.Semantic proximity Read

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors still improve metabolic phenotype in male 11β-HSD1 knockout mice suggesting off-target mechanisms.Semantic proximity Read

A combination of polymorphisms in HSD11B1 associates with in vivo 11β-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndromeSemantic proximity Read

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.Semantic proximity Read

Differential activity and expression of human 5β-reductase (AKR1D1) splice variantsSemantic proximity Read

Small Molecule 11β- Hydroxysteroid Dehydrogenase Type 1 InhibitorsSemantic proximity Read

Preadipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Keto-Reductase and Contributes to Diet-Induced Visceral Obesity in VivoSemantic proximity Read

Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism.Semantic proximity Read