Article

11β-HSD1 inhibitor efficacy in type 2 diabetes is cortisol-dependent

2024-05-10

Abstract excerpt

<h4>ABSTRACT</h4> Cortisol excess drives multiple adverse effects including hypertension, dyslipidemia, and delayed wound healing. Activation of cortisol by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) has shown promise as a therapeutic target for these comorbidities but clinical progress has been hampered by variable 11β-HSD1 inhibitor efficacy. Here, transcriptomic profiling of 11β-HSD1 target g...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 80088291-1280-5433-a151-333496c55255
DOI: 10.1101/2024.05.10.24307180

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

11β-HSD1 inhibitor efficacy in type 2 diabetes is cortisol-dependentDOI 10.1101/2024.05.10.24307180Read

A randomised controlled pilot trial of oral 11β-HSD1 inhibitor AZD4017 for wound healing in adults with type 2 diabetes mellitusSemantic proximity Read

Small Molecule 11β- Hydroxysteroid Dehydrogenase Type 1 InhibitorsSemantic proximity Read

Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 drives concurrent 11-oxygenated androgen excessSemantic proximity Read

11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects.Semantic proximity Read

Inhibition of skin glucocorticoid synthesis by topical metyrapone administration supports wound healing in diabetic miceSemantic proximity Read

11 beta-Hydroxysteroid dehydrogenase.Semantic proximity Read

11β-Hydroxysteroid Dehydrogenase-1 Is a Novel Regulator of Skin Homeostasis and a Candidate Target for Promoting Tissue RepairSemantic proximity Read

11beta-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle.Semantic proximity Read

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors still improve metabolic phenotype in male 11β-HSD1 knockout mice suggesting off-target mechanisms.Semantic proximity Read

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.Semantic proximity Read

Association of HSD11B1 gene polymorphisms with type 2 diabetes and metabolic syndrome in South Indian population.Semantic proximity Read

Global 11 beta-hydroxysteroid dehydrogenase activity assessed by the circulating cortisol to cortisone ratio is associated with features of metabolic syndromeSemantic proximity Read