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Article

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.

Endocrine reviews - 1 Oct 2004

Tomlinson Jeremy W, Walker Elizabeth A, Bujalska Iwona J, Draper Nicole, Lavery Gareth G, Cooper Mark S, Hewison Martin, Stewart Paul M

Abstract excerpt

11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) interconverts inactive cortisone and active cortisol. Although bidirectional, in vivo it is believed to function as a reductase generating active glucocorticoid at a prereceptor level, enhancing glucocorticoid receptor activation. In this r...

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Identifiers

PMID: 15466942
DOI: 10.1210/er.2003-0031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15466942-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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