Article

Immortalized Mesenchymal Stromal Cells Overexpressing Alpha-1 Antitrypsin Protect Acinar Cells from Apoptotic and Ferroptotic Cell Death

2023-08-09

Abstract excerpt

<title>Abstract</title><p>Chronic pancreatitis (CP) is a progressive inflammatory disorder that impairs endocrine and exocrine function. Our previous work suggests that mesenchymal stem/stromal cells (MSCs) and MSCs overexpressing alpha-1 antitrypsin (AAT-MSCs) could be therapeutic tools for CP treatment in mouse models. However, primary MSCs have a predisposition to undergo senescence during culture expansion whi...

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Literature Corpus work: 57af1bb6-f902-5e90-a20c-1270fd75f46c
DOI: 10.21203/rs.3.rs-2961444/v1

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