Article
Use of ultrasound-guided small joint biopsy to evaluate the histopathologic response to rheumatoid arthritis therapy: recommendations for application to clinical trials.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Oct 2015
Humby Frances, Kelly Stephen, Hands Rebecca, Rocher Vidalba, DiCicco Maria, Ng Nora, Zou Lu, Bugatti Serena, Manzo Antonio, Caporali Roberto, Montecucco Carlomaurizio, Bombardieri Michele, Pitzalis Costantino
Abstract excerpt
OBJECTIVE: To examine in a cohort of rheumatoid arthritis (RA) patients undergoing serial ultrasound (US)-guided biopsies of small joints in the context of clinical trials whether sufficient synovial tissue could be obtained at both baseline and second biopsy to: 1) accurately evaluate the synovial immune phenotype, 2) permit adequate RNA extraction to determine molecular signatures, and 3) sensitively detect...
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