Article

Efficient Inference of Direct Gene--Gene Associations via High-Dimensional Precision Matrix with Rigorous FDR Control

2026-02-23

Abstract excerpt

<title>Abstract</title> Gene coexpression networks (GCNs) provide a useful representation of coordinated gene activity, but their reconstruction from single-cell RNA sequencing (scRNA-seq) data is challenged by high dimensionality, sparsity and heterogeneous noise. Most existing approaches rely on marginal correlation or machine-learning regressors, which tend to capture indirect associations and typically lac...

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Literature Corpus work: 57578454-7dca-5190-a4dc-3437a81cb865
DOI: 10.21203/rs.3.rs-8830834/v1

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