Article

Aggregation of <i>recount3</i> RNA-seq data improves inference of consensus and tissue-specific gene co-expression networks

2024-01-22

Abstract excerpt

<h4>Background</h4> Gene co-expression networks (GCNs) describe relationships among expressed genes key to maintaining cellular identity and homeostasis. However, the small sample size of typical RNA-seq experiments which is several orders of magnitude fewer than the number of genes is too low to infer GCNs reliably. recount3 , a publicly available dataset comprised of 316,443 uniformly processed human RNA-seq s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f7c89ec-f7e5-51da-81e4-d6a8209af131
DOI: 10.1101/2024.01.20.576447

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aggregation of <i>recount3</i> RNA-seq data improves inference of consensus and tissue-specific gene co-expression networksDOI 10.1101/2024.01.20.576447Read

Co-expression networks reveal the tissue-specific regulation of transcription and splicingSemantic proximity Read

Co-expression networks reveal the tissue-specific regulation of transcription and splicing.Semantic proximity Read

Single-Cell Transcriptomics Unveils Gene Regulatory Network PlasticitySemantic proximity Read

Augmenting the human interactome for disease prediction through gene networks inferred from human cell atlasSemantic proximity Read

Cell-type-specific co-expression inference from single cell RNA-sequencing dataSemantic proximity Read

Integrative networks illuminate biological factors underlying gene-disease associationsSemantic proximity Read

Evaluation of critical data processing steps for reliable prediction of gene co-expression from large collections of RNA-seq dataSemantic proximity Read

Interpretable joint clustering of single-cell transcriptomesSemantic proximity Read

FastGxC: Fast and Powerful Context-Specific eQTL Mapping in Bulk and Single-Cell DataSemantic proximity Read

Joint Gene Network Construction by Single-Cell RNA Sequencing DataSemantic proximity Read

Gene expression data analysis using Hellinger correlation in weighted gene co-expression networks (WGCNA)Semantic proximity Read

Efficient Inference of Direct Gene--Gene Associations via High-Dimensional Precision Matrix with Rigorous FDR ControlSemantic proximity Read