Article

Optimized transcriptional signature for evaluation of MEK/ERK pathway baseline activity and long-term modulations in ovarian cancer

2022-03-23

Abstract excerpt

<h4>ABSTRACT</h4> Ovarian cancer is the most aggressive and lethal of all gynecologic malignancies. High activity of the MEK/ERK signaling pathway is tightly associated with tumor growth, high recurrence rate, and treatment resistance. Several transcriptional signatures were proposed recently for evaluation of MEK/ERK activity in tumor tissue. In the present study, we validated the performance of a robust multi-c...

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Literature Corpus work: 574747ba-b822-5518-876a-abadc36dbb5f
DOI: 10.1101/2022.03.21.485160

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