Article

Immediate myeloid depot for SARS-CoV-2 in the human lung

2022-05-17

Abstract excerpt

<title>Abstract</title> <p>In the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic1, considerable focus has been placed on a model of viral entry into host epithelial populations, with a separate focus upon the responding immune system dysfunction that exacerbates or causes disease. We developed a precision-cut lung slice model2,3 to investigate very early host-viral pathogenesis and found th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 57450958-9e84-52c0-9a19-9b1ddb06036f
DOI: 10.21203/rs.3.rs-1639631/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immediate myeloid depot for SARS-CoV-2 in the human lungDOI 10.21203/rs.3.rs-1639631/v1Read

Immediate myeloid depot for SARS-CoV-2 in the human lungSemantic proximity Read

Activated interstitial macrophages are a predominant target of viral takeover and focus of inflammation in COVID-19 initiation in human lungSemantic proximity Read

Surfactant deficiency increases SARS-CoV-2 canonical and non-canonical viral entry to lung epithelial cells and exacerbates intrapulmonary inflammatory responsesSemantic proximity Read

Alveolitis in severe SARS-CoV-2 pneumonia is driven by self-sustaining circuits between infected alveolar macrophages and T cellsSemantic proximity Read

SARS-CoV2 infection in whole lung primarily targets macrophages that display subset-specific responsesSemantic proximity Read

Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19Semantic proximity Read

<i>Ex vivo</i> modelling of lung tissue resident antimicrobial responsesSemantic proximity Read

A precision-cut lung slice platform for evaluating respiratory virus replication dynamicsSemantic proximity Read

Distinct Pulmonary Innate and Adaptive Immune Responses during the Initiation and Resolution of Natural and Breakthrough SARS-CoV-2 InfectionSemantic proximity Read

Adult stem cell-derived complete lung organoid models emulate lung disease in COVID-19Semantic proximity Read

Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2Semantic proximity Read

An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacySemantic proximity Read