Article

Scalable Production and Purification of Engineered ARRDC1-Mediated Microvesicles in a HEK293 Suspension Cell System

2024-05-17

Abstract excerpt

The engineering of human ARRDC1-mediated microvesicles (ARMMs) as new non-viral vehicles for delivery of gene therapies overcomes challenges associated with current modalities. Hurdles such as generating sufficient material to meet demand and development of appropriate characterization assays, however, persist. Our study evaluated two scalable strategies to generate GFP-loaded ARMMs, transient transfection or stab...

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Literature Corpus work: facd1162-e8b2-57fa-ba57-5035b4aa4fe3
DOI: 10.1101/2024.05.14.594090

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