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Non-viral gene editing <i>in utero</i> with lipid nanoparticles complexed to mRNA

2022-10-16

Abstract excerpt

Nanoparticle-based drug delivery systems have the potential to revolutionize medicine but their low vascular permeability and rapid clearance by phagocytic cells have limited their medical impact. Nanoparticles delivered at the in utero stage have the potential to overcome these key limitations, due to the high rate of angiogenesis and cell division in fetal tissue, and the under-developed immune system. However,...

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Identifiers and source

Literature Corpus work
dc53fb30-b8ad-5155-aeec-bc07ff0f64a7
DOI
10.1101/2022.10.14.512310
Open publication

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Non-viral gene editing <i>in utero</i> with lipid nanoparticles complexed to mRNADOI 10.1101/2022.10.14.512310
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