Article
Genetic evidence of a precisely tuned dysregulation in the hypoxia signaling pathway during oncogenesis.
Cancer research - 15 Nov 2014
Couvé Sophie, Ladroue Charline, Laine Elodie, Mahtouk Karène, Guégan Justine, Gad Sophie, Le Jeune Hélène, Le Gentil Marion, Nuel Gregory, Kim William Y, Lecomte Bernard, Pagès Jean-Christophe, Collin Christine, Lasne Françoise, Benusiglio Patrick R, Bressac-de Paillerets Brigitte, Feunteun Jean, Lazar Vladimir, Gimenez-Roqueplo Anne-Paule, Mazure Nathalie M, Dessen Philippe, Tchertanov Luba, Mole David R, Kaelin William, Ratcliffe Peter, Richard Stéphane, Gardie Betty
Abstract excerpt
The classic model of tumor suppression implies that malignant transformation requires full "two-hit" inactivation of a tumor-suppressor gene. However, more recent work in mice has led to the proposal of a "continuum" model that involves more fluid concepts such as gene dosage-sensitivity and tissue specificity. Mutations in the tumor-suppressor gene von Hippel-Lindau (VHL) are associated with a complex spectrum...
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