Article

Widespread FUS mislocalization is a molecular hallmark of ALS

2019-04-09

Abstract excerpt

Amyotrophic lateral sclerosis (ALS)-causing mutations clearly implicate ubiquitously expressed and predominantly nuclear RNA binding proteins (RBPs), which form pathological cytoplasmic inclusions in this context. However, the possibility that wild-type RBPs mislocalize without necessarily becoming constituents of ALS cytoplasmic inclusions themselves remains unexplored. We hypothesized that nuclear-to-cytoplasmic...

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Literature Corpus work: 3f0d23b9-f1bb-51b5-a3d7-45aac9274fb9
DOI: 10.1101/491787

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