Article

Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer

2021-02-02

Abstract excerpt

In a multi-level ‘deconstruction’ of omental metastases, we previously identified a prognostic matrisome gene expression signature in high-grade serous ovarian cancer (HGSOC) and twelve other malignancies. Here, our aim was to understand how six of these extracellular matrix, ECM, molecules, COL11A1, COMP, FN1, VCAN, CTSB and COL1A1, are up-regulated in cancer. Using biopsies, we identified significant association...

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Literature Corpus work: a3eae0c5-15e9-5364-a03b-36da04bb72fd
DOI: 10.1101/2021.02.01.428374

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