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Article

Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer

11 Jul 2017

Abstract excerpt

Advanced colorectal cancer (CRC) remains a critical health care challenge worldwide. Various TGF-β superfamily members are important in colorectal cancer metastasis, but their signaling effects and predictive value have only been assessed in isolation. Here, we examine cross-regulation and combined functions of the two most prominent TGF-β superfamily members activin and TGF-β in advanced colorectal cancer. In...

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PMID: 28717230
DOI: 10.1038/s41598-017-05907-8

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